Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.

نویسندگان

  • Brandyn R West
  • Kathryn M Hastie
  • Erica Ollmann Saphire
چکیده

The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPΔ340) was determined to 2.0 Å resolution. The structure indicates that LCMV NPΔ340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.

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عنوان ژورنال:
  • Acta crystallographica. Section D, Biological crystallography

دوره 70 Pt 6  شماره 

صفحات  -

تاریخ انتشار 2014